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AZD 6482
CAS No. 1173900-33-8
AZD 6482 ( AZD6482;AZD-6482;KIN-193;KIN 193;KIN193 )
Catalog No. M10586 CAS No. 1173900-33-8
A potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 115 | In Stock |
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| 25MG | 236 | In Stock |
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| 50MG | 441 | In Stock |
|
| 100MG | 644 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD 6482
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM.
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DescriptionA potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM; dispalys weak activity over PI3Kδ/PI3Kα/PI3Kγ/DNA-PK (IC50=80/870/1090/420 nM); potently inhibits Akt(Ser 473) phosphorylation in adenocarcinoma MDA-MB-468 cells (IC50=40 nM); inhibits insulin-induced human adipocyte glucose uptake in vitro (IC50=4.4 uM).Thrombosis Discontinued
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SynonymsAZD6482;AZD-6482;KIN-193;KIN 193;KIN193
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorDNA-PK;PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number1173900-33-8
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Formula Weight408.45
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Molecular FormulaC22H24N4O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC[C@@H](NC1=CC=CC=C1C(O)=O)C1=CC(C)=CN2C(=O)C=C(N=C12)N1CCOCC1 |r,c:5,7,16,21,t:3,13,23|
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Chemical NameBenzoic acid, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Giordanetto F, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3936-43.
2. Nylander S, et al. J Thromb Haemost. 2012 Oct;10(10):2127-36.
3. Laurent PA, et al. Blood. 2015 Jan 29;125(5):881-8.
2. Nylander S, et al. J Thromb Haemost. 2012 Oct;10(10):2127-36.
3. Laurent PA, et al. Blood. 2015 Jan 29;125(5):881-8.
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